Sulfate　radical-based　advanced　oxidation　processes　(SR-AOPs)　is　considered　as　one　of　the　most　promising　technologies　for　antibiotic　pollution.　In　this　study,　a　core-shell　catalyst　of　cobalt-manganese　oxide　derived　from　CoMn-MOFs　coating　by　MgAl-LDH　(Co/Mn@LDH)　was　synthesized　for　peroxymonosulfate　(PMS)　activation　to　degrade　sulfamethoxazole　(SMX).　Degradation　efficiency　of　nearly　100%　and　a　mineralization　efficiency　of　68.3%　for　SMX　were　achieved　in　Co/Mn@LDH/PMS　system.　Mn　species　and　out　shell　MgAl-LDH　greatly　suppressed　the　cobalt　ions　leaching,　which　only　23　μg/L　Co　ions　were　detected　by　ICP　after　the　reaction.　SO4·-　was　identified　as　dominant　reactive　species　in　the　system.　Furthermore,　the　possible　reactive　sites　of　SMX　were　predicted　by　the　density　functional　theory　(DFT)　calculations.　And　the　intermediates　of　SMX　were　detected　by　LC-MS　and　the　degradation　pathway　was　proposed　based　on　the　results　above.　The　ECOSAR　results　suggested　the　intermediates　of　SMX　showed　a　relatively　low　toxicity　compared　to　SMX,　indicating　huge　potential　of　utilization　of　Co/Mn@LDH　in　SR-AOPs　system.　©　2023