The　key　components　in　service,　such　as　aero-engine　turbine　blades,　are　generally　bearing　complex　interactions　of　high　and　low　cycle　fatigue　loading.　It　is　essential　to　make　accurate　fatigue　life　predictions　for　these　components.　In　this　paper,　based　on　experimental　analysis　and　the　Miner＇s　rule,　a　combined　cycle　fatigue　life　prediction　model　is　proposed.　The　effect　of　the　loading　interaction　of　the　high　and　low　cycle　fatigue　is　considered　through　the　coupled　damage,　which　is　proposed　based　on　the　investigation　of　the　fatigue　test　results　and　does　not　require　additional　material　constants　except　for　the　S-N　curve　parameters.　The　applicability　of　the　proposed　model　is　validated　by　the　experimental　data　of　three　materials　and　the　turbine　blade.　Compared　with　the　T-K　model　and　Miner＇s　rule,　the　results　demonstrate　that　the　proposed　model　provides　high　precision　accuracy.　A　combined　high　and　low　cycle　fatigue　(CCF)　life　prediction　model　is　proposed,　considering　the　loading　interaction　effect.Coupled　damage　is　put　forward　to　consider　the　loading　interaction　effect.The　validation　results　show　that　the　proposed　model　provides　high　precision　accuracy.