Biomacromolecule　coating　on　biomedical　magnesium　alloys　have　generated　considerable　interest　for　the　improved　corrosion　resistance　and　biocompatibility.　Silk　fibroin　(SF)　based　on　aqueous　solvent　has　been　demonstrated　to　be　a　promising　coating　for　magnesium　alloy,　but　pretreatment　process　is　necessary　due　to　the　corrosion　susceptibility　to　water.　Herein,　the　SF　coating　with　hexafluoroisopropanol(HFIP)　solvent　was　prepared　without　preteatment　for　simplified　processing　and　enhanced　adhesion.　Ethylene　glycol　diglycidyl　ether(EGDE)　was　applied　to　stabilize　the　coating　with　more　chemical　crosslinking.　The　morphologies　and　nano-scratch　test　verify　that　the　compactness　and　adhesion　strength　of　HFIP　based　SF　are　better　than　that　of　aqueous　based　SF.　The　electrochemical　evaluation　and　in　vitro　degradation　in　simulated　body　fluid　indicated　that　the　HFIP　based　SF　coating　exhibited　significantly　enhanced　corrosion　resistance.　Moreover,　the　application　of　EGDE　post-treatment　significantly　improved　corrosion　resistance　(the　corrosion　current　density　Icoor　of　the　SF-HFIP-EGDE　samples　stands　at　9.93*10-10A　cm-2,　representing　a　reduction　by　two　orders　of　magnitude　in　comparison　to　pure　SF　samples).　Cytoskeleton,　cell　adhesion　and　cytotoxicity　tests　with　MC3T3-E1　cells　verifies　the　improved　cell　adhesion　and　biological　activity　of　silk　coating.　This　study　provides　a　simple　method　for　physical　deposition　of　biomacromolecule　coatings　on　magnesium　alloys,　while　improving　adhesion　and　corrosion　resistance.