• 综合
  • 标题
  • 关键词
  • 摘要
  • 学者
  • 期刊-刊名
  • 期刊-ISSN
  • 会议名称
搜索

作者:

Zhang, Honghui (Zhang, Honghui.) | Song, Xiaorui (Song, Xiaorui.) | Wu, Rile (Wu, Rile.) | Li, Na (Li, Na.) | Hou, Qianwen (Hou, Qianwen.) | Xie, Jinjie (Xie, Jinjie.) | Hou, Yang (Hou, Yang.) | Qiao, Aike (Qiao, Aike.) (学者:乔爱科)

收录:

EI Scopus SCIE

摘要:

Boundary condition settings are key risk factors for the accuracy of noninvasive quantification of fractional flow reserve (FFR) based on computed tomography angiography (i.e., FFRCT). However, transient numerical simulation-based FFRCT often ignores the three-dimensional (3D) model of coronary artery and clinical statistics of hyperemia state set by boundary conditions, resulting in insufficient computational accuracy and high computational cost. Therefore, it is necessary to develop the custom function that combines the 3D model of the coronary artery and clinical statistics of hyperemia state for boundary condition setting, to accurately and quickly quantify FFRCT under steady-state numerical simulations. The 3D model of the coronary artery was reconstructed by patient computed tomography angiography (CTA), and coronary resting flow was determined from the volume and diameter of the 3D model. Then, we developed the custom function that took into account the interaction of stenotic resistance, microcirculation resistance, inlet aortic pressure, and clinical statistics of resting to hyperemia state due to the effect of adenosine on boundary condition settings, to accurately and rapidly identify coronary blood flow for quantification of FFRCT calculation (FFRU). We tested the diagnostic accuracy of FFRU calculation by comparing it with the existing methods (CTA, coronary angiography (QCA), and diameter-flow method for calculating FFR (FFRD)) based on invasive FFR of 86 vessels in 73 patients. The average computational time for FFRU calculation was greatly reduced from 1-4 h for transient numerical simulations to 5 min per simulation, which was 2-fold less than the FFRD method. According to the results of the Bland-Altman analysis, the consistency between FFRU and invasive FFR of 86 vessels was better than that of FFRD. The area under the receiver operating characteristic curve (AUC) for CTA, QCA, FFRD and FFRU at the lesion level were 0.62 (95% CI: 0.51-0.74), 0.67 (95% CI: 0.56-0.79), 0.85 (95% CI: 0.76-0.94), and 0.93 (95% CI: 0.87-0.98), respectively. At the patient level, the AUC was 0.61 (95% CI: 0.48-0.74) for CTA, 0.65 (95% CI: 0.53-0.77) for QCA, 0.83 (95% CI: 0.74-0.92) for FFRD, and 0.92 (95% CI: 0.89-0.96) for FFRU. The proposed novel method might accurately and rapidly identify coronary blood flow, significantly improve the accuracy of FFRCT calculation, and support its wide application as a diagnostic indicator in clinical practice.

关键词:

boundary condition setting fractional flow reserve steady-state numerical simulations noninvasive quantification custom function

作者机构:

  • [ 1 ] [Zhang, Honghui]Inner Mongolia Minzu Univ, Coll Engn, Key Lab Intelligent Mfg Technol, Tongliao, Peoples R China
  • [ 2 ] [Zhang, Honghui]Beijing Univ Technol, Fac Environm & Life, Beijing, Peoples R China
  • [ 3 ] [Hou, Qianwen]Beijing Univ Technol, Fac Environm & Life, Beijing, Peoples R China
  • [ 4 ] [Qiao, Aike]Beijing Univ Technol, Fac Environm & Life, Beijing, Peoples R China
  • [ 5 ] [Song, Xiaorui]Shandong First Med Univ & Shandong Acad Med Sci, Sch Clin, Jinan, Peoples R China
  • [ 6 ] [Li, Na]Shandong First Med Univ & Shandong Acad Med Sci, Sch Clin, Jinan, Peoples R China
  • [ 7 ] [Wu, Rile]Tong Liao City Hosp, Dept Neurol, Tongliao, Peoples R China
  • [ 8 ] [Xie, Jinjie]Capital Med Univ, Beijing Anzhen Hosp, Beijing, Peoples R China
  • [ 9 ] [Xie, Jinjie]Jiahui Int Hosp, Dept Gastroenterol, Shanghai, Peoples R China
  • [ 10 ] [Hou, Yang]China Med Univ, Shengjing Hosp, Shenyang, Peoples R China

通讯作者信息:

电子邮件地址:

查看成果更多字段

相关关键词:

来源 :

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY

ISSN: 2296-4185

年份: 2023

卷: 11

5 . 7 0 0

JCR@2022

被引次数:

WoS核心集被引频次:

SCOPUS被引频次: 1

ESI高被引论文在榜: 0 展开所有

万方被引频次:

中文被引频次:

近30日浏览量: 0

归属院系:

在线人数/总访问数:535/4950823
地址:北京工业大学图书馆(北京市朝阳区平乐园100号 邮编:100124) 联系我们:010-67392185
版权所有:北京工业大学图书馆 站点建设与维护:北京爱琴海乐之技术有限公司