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Author:

Wang, Huina (Wang, Huina.) | Liu, Bo (Liu, Bo.) | Long, Junqi (Long, Junqi.) | Yu, Jiangyong (Yu, Jiangyong.) | Ji, Xinchan (Ji, Xinchan.) | Li, Jinmeng (Li, Jinmeng.) | Zhu, Nian (Zhu, Nian.) | Zhuang, Xujie (Zhuang, Xujie.) | Li, Lujia (Li, Lujia.) | Chen, Yuhaoran (Chen, Yuhaoran.) | Liu, Zhidong (Liu, Zhidong.) | Wang, Shu (Wang, Shu.) | Zhao, Shuangtao (Zhao, Shuangtao.)

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Scopus SCIE

Abstract:

Comprehensive multiplatform analysis of Luminal B breast cancer (LBBC) specimens identifies two molecularly distinct, clinically relevant subtypes: Cluster A associated with cell cycle and metabolic signaling and Cluster B with predominant epithelial mesenchymal transition (EMT) and immune response pathways. Wholeexome sequencing identified significantly mutated genes including TP53, PIK3CA, ERBB2, and GATA3 with recurrent somatic mutations. Alterations in DNA methylation or transcriptomic regulation in genes (FN1, ESR1, CCND1, and YAP1) result in tumor microenvironment reprogramming. Integrated analysis revealed enriched biological pathways and unexplored druggable targets (cancer-testis antigens, metabolic enzymes, kinases, and transcription regulators). A systematic comparison between mRNA and protein displayed emerging expression patterns of key therapeutic targets (CD274, YAP1, AKT1, and CDH1). A potential ceRNA network was developed with a significantly different prognosis between the two subtypes. This integrated analysis reveals a complex molecular landscape of LBBC and provides the utility of targets and signaling pathways for precision medicine.

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Author Community:

  • [ 1 ] [Wang, Huina]Beijing Univ Technol, Fac Informat Technol, Sch Software Engn, Beijing 100124, Peoples R China
  • [ 2 ] [Long, Junqi]Beijing Univ Technol, Fac Informat Technol, Sch Software Engn, Beijing 100124, Peoples R China
  • [ 3 ] [Ji, Xinchan]Beijing Univ Technol, Fac Informat Technol, Sch Software Engn, Beijing 100124, Peoples R China
  • [ 4 ] [Li, Jinmeng]Beijing Univ Technol, Fac Informat Technol, Sch Software Engn, Beijing 100124, Peoples R China
  • [ 5 ] [Zhu, Nian]Beijing Univ Technol, Fac Informat Technol, Sch Software Engn, Beijing 100124, Peoples R China
  • [ 6 ] [Zhuang, Xujie]Beijing Univ Technol, Fac Informat Technol, Sch Software Engn, Beijing 100124, Peoples R China
  • [ 7 ] [Li, Lujia]Beijing Univ Technol, Fac Informat Technol, Sch Software Engn, Beijing 100124, Peoples R China
  • [ 8 ] [Chen, Yuhaoran]Beijing Univ Technol, Fac Informat Technol, Sch Software Engn, Beijing 100124, Peoples R China
  • [ 9 ] [Liu, Zhidong]Beijing Univ Technol, Fac Informat Technol, Sch Software Engn, Beijing 100124, Peoples R China
  • [ 10 ] [Liu, Bo]Massey Univ, Sch Math & Computat Sci, Palmerston North 4472, New Zealand
  • [ 11 ] [Yu, Jiangyong]Chinese Acad Med Sci, Beijing Hosp, Inst Geriatr Med, Natl Ctr Gerontol,Dept Med Oncol, Beijing 100730, Peoples R China
  • [ 12 ] [Liu, Zhidong]Capital Med Univ, Beijing Chest Hosp, Beijing TB & Thorac Tumor Res Inst, Dept Thorac Surg, Beijing 101149, Peoples R China
  • [ 13 ] [Zhao, Shuangtao]Capital Med Univ, Beijing Chest Hosp, Beijing TB & Thorac Tumor Res Inst, Dept Thorac Surg, Beijing 101149, Peoples R China
  • [ 14 ] [Wang, Shu]Peking Univ, Hosp 1, Breast Dis Ctr, Beijing 100044, Peoples R China

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Source :

ISCIENCE

Year: 2023

Issue: 9

Volume: 26

5 . 8 0 0

JCR@2022

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count: 4

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 1

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