The　experimental　investigation　about　oblique　incidence　of　earthquake　wave　on　seismic　response　of　large　span　spatial　grid　structure　was　lack　at　the　present　stage.Based　on　a　model　box　of　7.7m　length,3.2m　width　and　1.2m　depth,and　a　single-layer　cylindrical　reticulated　shell　of　1.8m　length　and　1.8m　span,at　the　same　time,the　soil　parameters　were　measured,a　free　field　shaking　test　and　a　shaking　table　test　of　soil-single-layer　reticulated　cylindrical　shell　interaction　were　realized　by　four　array　shaking　table　system.The　correctness　of　the　shaking　test　design　was　verified　by　comparing　the　results　of　free　field　shaking　table　test　and　numerical　simulation,then　the　seismic　response　of　the　soil-single-layer　cylindrical　reticulated　shell　system　subjected　to　oblique　incidence　wave　was　studied.Experimental　investigation　showed　that　the　seismic　response　of　the　reticulated　shell　presents　obvious　nonlinear　variation　with　the　increase　of　the　incident　angle　of　seismic　wave.Especially　when　the　seismic　wave　was　input　from　30°　to　60°,the　seismic　response　of　the　reticulated　shell　was　violent.The　maximum　ratio　of　the　horizontal　acceleration　at　the　bottom　of　the　reticulated　shell　column　was　between　1:0.3　and　1:3.When　the　seismic　calculation　was　carried　out,the　acceleration　input　ratio　of　the　two　horizontal　direction　of　the　column　base　was　related　to　the　incident　angle　of　the　seismic　wave,and　the　spatial　effect　of　oblique　incidence　of　earthquake　wave　should　be　considered　carefully.　©　2018,　Science　Press.　All　right　reserved.