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作者:

Xia, Yang (Xia, Yang.) | Li, Jintao (Li, Jintao.) | Li, Shuying (Li, Shuying.) | Khodahemmati, Sara (Khodahemmati, Sara.) | Ghaffar, Maliha (Ghaffar, Maliha.) | Chen, Su (Chen, Su.) | Sheng, Wang (Sheng, Wang.) (学者:盛望)

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SCIE PubMed

摘要:

Human papillomavirus (HPV) infection was associated with some carcinomas, especially malignant tumors in upper digestive tract, upper respiratory tract, and genitourinary system. The mechanism of the viral transformation of normal cells is still not very clear. To investigate the tumorigenesis of epithelial cells, E6/E7-induced malignant transformation model cells were used for expression profiling analysis by performing RNA expression microarray detection. Bioinformatics analysis was applied to investigate the cellular process changes along with the E6/E7 expression in SHEE cells. The differentially expressed genes were further grouped and uploaded for Search Tool for the Retrieval of Interacting Genes analysis. The protein-protein interaction results were visualized. The hub genes and their first-neighbors genes were selected, followed by gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis. The obtained results demonstrated that tumor-related biological processes began to emerge during the carcinogenesis process from 48th passage to 76th passage of SHEE cells after E6/E7 expression. Ten hub genes were identified and analyzed during the E6/E7-induced tumorigenesis. This study explores the gene expression network in the progressive transformation of immortalized esophageal epithelial cells induced by E6/E7 expression. Understanding the biological processes and hub genes that first appear during the transformation will provide some clues to the mechanism of E6/E7-induced carcinogenesis of esophageal epithelial cells.

关键词:

bioinformatics E6 E7 esophageal epithelial cells HPV

作者机构:

  • [ 1 ] [Xia, Yang]Beijing Univ Technol, Beijing Key Lab Environm & Viral Oncol, Beijing Int Sci & Technol Cooperat Base Antivirus, 100 Pingleyuan, Beijing 100124, Peoples R China
  • [ 2 ] [Li, Jintao]Beijing Univ Technol, Beijing Key Lab Environm & Viral Oncol, Beijing Int Sci & Technol Cooperat Base Antivirus, 100 Pingleyuan, Beijing 100124, Peoples R China
  • [ 3 ] [Khodahemmati, Sara]Beijing Univ Technol, Beijing Key Lab Environm & Viral Oncol, Beijing Int Sci & Technol Cooperat Base Antivirus, 100 Pingleyuan, Beijing 100124, Peoples R China
  • [ 4 ] [Ghaffar, Maliha]Beijing Univ Technol, Beijing Key Lab Environm & Viral Oncol, Beijing Int Sci & Technol Cooperat Base Antivirus, 100 Pingleyuan, Beijing 100124, Peoples R China
  • [ 5 ] [Sheng, Wang]Beijing Univ Technol, Beijing Key Lab Environm & Viral Oncol, Beijing Int Sci & Technol Cooperat Base Antivirus, 100 Pingleyuan, Beijing 100124, Peoples R China
  • [ 6 ] [Xia, Yang]South China Univ Technol, Sch Mat Sci & Engn, Guangzhou, Guangdong, Peoples R China
  • [ 7 ] [Li, Shuying]North China Univ Sci & Technol, Hebei Key Lab Chron Dis, Tangshan Key Lab Preclin & Basic Res Chron Dis, Qinhuangdao, Hebei, Peoples R China
  • [ 8 ] [Chen, Su]Hubei Key Lab Med Informat Anal & Tumor Diag & Tr, Wuhan, Hubei, Peoples R China
  • [ 9 ] [Ghaffar, Maliha]Univ Okara, Dept Biol Zool, Okara, Pakistan

通讯作者信息:

  • 盛望

    [Li, Jintao]Beijing Univ Technol, Beijing Key Lab Environm & Viral Oncol, Beijing Int Sci & Technol Cooperat Base Antivirus, 100 Pingleyuan, Beijing 100124, Peoples R China;;[Sheng, Wang]Beijing Univ Technol, Beijing Key Lab Environm & Viral Oncol, Beijing Int Sci & Technol Cooperat Base Antivirus, 100 Pingleyuan, Beijing 100124, Peoples R China

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来源 :

JOURNAL OF MEDICAL VIROLOGY

ISSN: 0146-6615

年份: 2020

期: 12

卷: 92

页码: 3736-3742

1 2 . 7 0 0

JCR@2022

ESI学科: MICROBIOLOGY;

ESI高被引阀值:61

JCR分区:4

被引次数:

WoS核心集被引频次: 13

SCOPUS被引频次:

ESI高被引论文在榜: 0 展开所有

万方被引频次:

中文被引频次:

近30日浏览量: 5

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