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作者:

Liu, Haiying (Liu, Haiying.) | Zhao, Yongzheng (Zhao, Yongzheng.) | Zhao, Sen (Zhao, Sen.) | Feng, Jingjing (Feng, Jingjing.) | Zhang, Chunqiu (Zhang, Chunqiu.)

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EI PKU CSCD

摘要:

Based on transversely isotropic theory, a finite element model for three-dimensional solid-liquid coupling defect repair of articular cartilage was established. By studying stress state of host cartilage near the restoration interface, we identified deformation type of cartilage and discussed the cause of restoration interface cracking. The results showed that the host cartilage surface node near the restoration interface underwent compression deformation in the condition of surface layer defect repair. When the middle layer, deep layer or full-thickness defect were repaired, the node underwent tensile deformation. At this point, the radial dimension of cartilage increased, which might cause restoration interface cracking. If elastic modulus of the tissue engineered cartilage (TEC) was lower (0.1 MPa, 0.3 MPa), the host cartilage surface layer and middle layer mainly underwent tensile deformation. While elastic modulus of TEC was higher (0.6 MPa, 0.9 MPa), each layer of host cartilage underwent compression deformation. Therefore, the elastic modulus of TEC could be increased properly for full-thickness defect repair. This article provides a new idea for evaluating the effect of cartilage tissue engineering repair, and has a certain guiding significance for clinical practice. Copyright © 2018 by Editorial Office of Journal of Biomedical Engineering.

关键词:

Cartilage Cracks Deformation Elastic moduli Interface states Restoration Tissue Tissue engineering

作者机构:

  • [ 1 ] [Liu, Haiying]Tianjin Key Laboratory for Advanced Mechatronic System Design and Intelligent Control, Tianjin; 300384, China
  • [ 2 ] [Liu, Haiying]National Demonstration Center for Experimental Mechanical and Electrical Engineering Education, Tianjin University of Technology, Tianjin; 300384, China
  • [ 3 ] [Zhao, Yongzheng]Tianjin Key Laboratory for Advanced Mechatronic System Design and Intelligent Control, Tianjin; 300384, China
  • [ 4 ] [Zhao, Yongzheng]National Demonstration Center for Experimental Mechanical and Electrical Engineering Education, Tianjin University of Technology, Tianjin; 300384, China
  • [ 5 ] [Zhao, Sen]Tianjin Key Laboratory for Advanced Mechatronic System Design and Intelligent Control, Tianjin; 300384, China
  • [ 6 ] [Zhao, Sen]National Demonstration Center for Experimental Mechanical and Electrical Engineering Education, Tianjin University of Technology, Tianjin; 300384, China
  • [ 7 ] [Feng, Jingjing]Tianjin Key Laboratory for Advanced Mechatronic System Design and Intelligent Control, Tianjin; 300384, China
  • [ 8 ] [Feng, Jingjing]National Demonstration Center for Experimental Mechanical and Electrical Engineering Education, Tianjin University of Technology, Tianjin; 300384, China
  • [ 9 ] [Feng, Jingjing]Beijing University of Technology, College of Mechanical Engineering, Beijing; 100124, China
  • [ 10 ] [Zhang, Chunqiu]Tianjin Key Laboratory for Advanced Mechatronic System Design and Intelligent Control, Tianjin; 300384, China
  • [ 11 ] [Zhang, Chunqiu]National Demonstration Center for Experimental Mechanical and Electrical Engineering Education, Tianjin University of Technology, Tianjin; 300384, China

通讯作者信息:

  • [liu, haiying]tianjin key laboratory for advanced mechatronic system design and intelligent control, tianjin; 300384, china;;[liu, haiying]national demonstration center for experimental mechanical and electrical engineering education, tianjin university of technology, tianjin; 300384, china

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来源 :

Journal of Biomedical Engineering

ISSN: 1001-5515

年份: 2018

期: 5

卷: 35

页码: 705-712 and 719

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