Recently,　a　novel　proof-of-concept　oxygen　reduction　reaction　(ORR)　based　electro-oxidation　(EO)　process　has　been　developed,　which　was　accomplished　by　integrating　anodic　electrochemical　oxidation　coupled　with　an　in　situ　electro-peroxone　process,　by　harnessing　the　anodic　by-product　O-3　reacted　with　ORR　cathode　generated　H2O2.　To　further　enhance　EO　coupled　in　situ　electro-peroxone,　a　nickel　and　antimony　doped　tin　oxide　anodic　catalyst　layer,　namely　NATO,　was　fabricated　on　Ti　mesh　to　improve　anodic　oxidation　and　reinforce　the　generation　of　O-3,　thus　promoting　in　situ　Electro-peroxone.　As　a　result,　O-3　generation　rate　was　enhanced　by　12.6%.　Complete　phenol,　as　a　model　organic　compound,　and　95%　of　TOC　removal　were　achieved,　respectively,　during　ORR-EO.　Through　kinetics　and　instrument　analysis,　results　show　that　the　amount　of　intermediates　accumulated　during　phenol　degradation　was　much　less　in　this　Ti/NATO　based　ORR-EO　system　than　in　a　traditional　EO　system.　Moreover,　35.7%　of　the　energy　consumption　was　saved　for　ORR-EO,　owing　to　its　reduced　applied　voltage　and　the　enhanced　in　situ　electro-peroxone　process.