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作者:

Su, Dongdong (Su, Dongdong.) | Cheng, Dan (Cheng, Dan.) | Lv, Yun (Lv, Yun.) | Ren, Xiaojun (Ren, Xiaojun.) | Wu, Qian (Wu, Qian.) | Yuan, Lin (Yuan, Lin.)

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摘要:

Hydrogen sulfide (H2S) has been found to be an important biological regulator that plays important roles in many physiological and pathological processes. Near-infrared (NIR) fluorescent probes capable of selectively detecting H2S in vivo will be useful tools to understand its mechanisms in biological processes. Herein, we reported an easily synthesized and stimuli-responsive NIR fluorescent probe (QCy7-HS) for selective evaluation of endogenous H2S in the living cells and mice. In response to cellular H2S stimulus, QCy7-HS is converted to (tCy7 and shows a unique off-on near-infrared fluorescence signal change. The results of selectivity and kinetic studies indicated that our probe has high H2S binding capacity. Therefore, this probe was used for the fluorescence detection of H2S in cells. Moreover, the probe was applied for study exogenous and endogenous H2S in live mice, indicating that the new probe can be used as an efficient tool on H2S related events in living animals. (C) 2019 Elsevier B.V. All rights reserved.

关键词:

In vivo Fluorescence spectroscopy Near-infrared Off-on Hydrogen sulfide Fluorescent probe

作者机构:

  • [ 1 ] [Su, Dongdong]Beijing Univ Technol, Dept Chem & Chem Engn, Beijing 100124, Peoples R China
  • [ 2 ] [Ren, Xiaojun]Beijing Univ Technol, Dept Chem & Chem Engn, Beijing 100124, Peoples R China
  • [ 3 ] [Cheng, Dan]Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China
  • [ 4 ] [Lv, Yun]Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China
  • [ 5 ] [Wu, Qian]Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China
  • [ 6 ] [Yuan, Lin]Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China

通讯作者信息:

  • [Su, Dongdong]Beijing Univ Technol, Dept Chem & Chem Engn, Beijing 100124, Peoples R China;;[Yuan, Lin]Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China

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来源 :

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

ISSN: 1386-1425

年份: 2020

卷: 226

4 . 4 0 0

JCR@2022

ESI学科: CHEMISTRY;

ESI高被引阀值:139

被引次数:

WoS核心集被引频次: 24

SCOPUS被引频次: 25

ESI高被引论文在榜: 0 展开所有

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