The　adsorptive　removal　of　antibiotics,　emerging　organic　pollutants　in　water　is　very　important　but　challenging.　In　this　work　we　report　a　series　of　eight　water　stable　metal-organic　framework　(MOFs),　which　are　methodically　screened　for　the　removal　of　metronidazole　(MNZ)　from　water.　It　was　found　that　two　isostructural　Zr(IV)-MOFs　(UiO-66　and　UiO-66-NH2)　showed　adsorption　capacities　of　around　200.2　mg　g(-1)　and　265.5　mg　g(-1),　respectively,　which　are　higher　than　the　experimental　values　of　reported　porous　materials　used　for　MNZ　removal　so　far.　The　MOFs　were　characterized　by　Powder　X-ray　diffraction　(PXRD),　Fourier　transform　infrared　(FT-IR)　spectroscopy,　Thermogravimetric　analysis　(TGA),　Scanning　electron　microscope　(SEM),　Energy-dispersive　X-ray　elemental　analysis　(EDX),　BET　isotherm,　UV-vis　(UV-vis)　spectrophotometer　and　NICOMPT　380　ZLS.　The　effects　of　various　parameters　including　time,　concentration,　temperature　and　pH　were　investigated.　The　adsorption　mechanism　of　UiO-66-NH2　for　MNZ　has　also　been　explored　through　computational　simulations.　The　results　showed　that　MNZ　molecules　are　mainly　locate　at　around　the　-NH2　functional　groups　in　pore　surfaces　of　UiO-66-NH2,　with　the　increase　of　molecular　level　of　the　amino　groups,　the　affinity　of　the　framework　to　MNZ　could　be　significantly　increased.　The　results　demonstrated　that　highest　adsorption　uptake　by　UiO-66-NH2　was　attributed　to　-NH2　functional　group　including　with　(hydrogen　bonding　interactions,　electrostatic　interaction　and　larger　pHpzc).　The　adsorption　process　of　the　two　MOFs　fitted　the　pseudo-second-order　kinetic　model　and　Langmuir　isothermal　model,　whilst　the　adsorption　was　endothermic,　with　the　confirmation　by　thermodynamic　studies.