The　dual　(pH-　and　temperature-)　responsive　core-shell　structured　mesoporous　nanomaterial　P@BMMs　were　prepared　using　bimodal　mesoporous　silica　as　a　core　and　poly(N-isopropyla　crylamide-co-acrylic　acid)　P(NIPAM-co-AA)　copolymer　as　a　shell.　Ibuprofen　(IBU)　was　used　as　a　model　drug,　and　the　effects　of　copolymer-coated　shell　thickness　on　drug　loading　and　controlled　release　behavior　were　investigated　by　means　of　N-2　sorption　isotherms,　dynamic　light　scattering　measurements,　X-ray　diffraction　patterns,　Fourier　transform　infrared　spectra,　scanning　electron　and　transmission　electron　microscopy,　thermogravimetric　profiles,　and　elemental　analysis　techniques.　Particularly,　their　fractal　evolutions　in　the　drug　delivery　durations　were　explored　via　small　angle　X-ray　scattering　methods,　demonstrating　that　the　resultant　P@BMMs　before　IBU-loading　and　after　releasing　possess　the　typical　fractal　features　with　spherical　morphology.　Meanwhile,　the　estimation　for　shell　thickness　of　P@BMMs　coating　in　different　time　intervals　indicated　that　the　drug-loaded　capacity　was　improved　with　the　increasing　shell　thickness,　but　drug-released　rate　varies,　strongly　depending　on　both　shell　thickness　and　release　conditions.　The　drug　delivery　mechanism　was　preliminarily　explored,　following　the　Korsmeyer-Peppas　model.　Finally,　cytotoxicity　in　cell　and　pharmacokinetic　of　released-IBU　from　hybrid　nanocomposite　in　mice　via　intravenously　injection　were　preliminarily　explored.　(C)　2019　Production　and　hosting　by　Elsevier　B.V.　on　behalf　of　King　Saud　University.