This　paper　analyses　inflatable　membrane　gas　holders＇　wind　effect　under　the　exponential　wind　speed　profile　flow.　The　internal　gas　is　considered　as　ideal　gas,　while　the　external　air　is　considered　as　an　incompressible　fluid.　A　partitioned　scheme　is　used　for　this　simulation,　namely　the　structure　domain　and　fluid　domain　were　simulated　by　the　commercial　software　FLUENT　and　ABAQUS　respectively,　and　the　coupling　between　the　fluid　and　structure　is　accomplished　by　use　of　a　method　with　real-time　transmission　between　fluid　dynamic　loads　and　structure　response　data　based　on　the　commercial　software　MpCCI.　Results　show　that　structural　unstability　occurs　when　considering　the　effect　of　fluid-structure　interaction(FSI)　under　certain　wind　speed,　but　the　structure　is　stable　when　not　considering　this　effect.　The　inflatable　membrane　gas　holder　structure　has　obvious　aero-elastic　effects　under　wind　loads,　therefore　fluid-structure　interaction　should　be　considered　during　the　wind-induced　vibration　analysis.　Copyright　©　2017　by　Yanli　He　and　Jihua　Shen.