Various　single-atom　materials　exhibit　distinguished　performances　in　catalysis　and　biology.　To　boost　their　applications,　single-atom-based　strategies　are　highly　demanded　to　exhibit　repeatable　functions　on　advanced　wearable　substrates.　However,　single-atom　approaches　are　rarely　reported　to　anchor　on　wearable　materials,　i.e.,　widely　applied　cotton　fabrics.　Here,　we　developed　a　simple　method　of　loading　uniformly　dispersed　single　tungsten　atoms　on　cotton　via　ordinary　direct-dye　processing　to　exhibit　superior　sustainable　functions.　The　single　sites　of　tungsten　atom　centers　are　constructed　by　binding　oxygen-coordinated　single　tungsten　atom　on　the　cotton　fabric　surface　via　-COOH　groups.　Consequently,　the　band　gap　of　single　sites　decreases　significantly　to　2.75　from　3.03　eV.　Therefore,　the　single-site-modified　cotton　exhibits　excellent　visible-light-driven　(＞420　nm)　photocatalytic　degradation　efficiency　of　organic　dyes,　which　exceeds　other　reported　cotton-based　materials　by　nearly　two　orders　of　magnitude.　Furthermore,　the　single-site-modified　cotton　also　exhibits　great　antibacterial　performance　due　to　reactive　oxygen　species.　Moreover,　the　cotton　with　anchored　single　sites　possesses　great　washing-resistance　ability　during　20　laundry　cycles　under　soap-washing　conditions.　After　recycling,　the　single　sites　on　cotton　have　no　obvious　changes　in　the　microstructure,　which　demonstrates　the　success　of　our　sustainable　strategy　of　single　sites　anchored　on　cotton.　The　single-site　technique　can　be　extended　to　many　other　elemental　atoms　on　various　wearable　devices,　providing　a　playground　for　functional　material　communities.　©　2021　American　Chemical　Society.