In　order　to　study　the　suitability　and　seismic　response　characteristics　of　the　nuclear　power　plants　on　non-rock　site,　taking　CAP1400　nuclear　power　plant　(NPP)　structure　as　an　example,　the　shaking　table　test　considering　soil-structure　interaction　(SSI)　was　completed.　The　test　study　indicates　that　the　site　can　amplify　the　peak　acceleration　which　presents　in　all　different　directions,　and　the　structure　can　influence　the　site　response　spectra　in　low　frequency.　Cracks　appear　on　the　model　site　when　inputting　less　than　safe　shut-down　earthquake　(SSE),　and　the　contact　surface　between　the　structure　and　the　soil　separates　when　inputting　safe　shut-down　earthquake　(SSE).　At　the　end　of　the　test,　the　surface　cracks　on　the　model　site　were　connected.　The　model　structure　had　no　crack.　The　damage　of　the　model　system　was　due　to　the　instability　of　the　foundation.　It　was　obvious　that　the　seismic　response　of　the　NPP　was　affected　by　site　conditions,　thus　the　site　conditions　and　the　soil　structure　interaction　(SSI)　analysis　should　be　taken　into　account　in　the　seismic　response　analysis　of　the　NPP.　©　2017,　Editorial　Board　of　Journal　of　Nuclear　Power　Engineering.　All　right　reserved.