Research　purposes:　For　the　aim　to　further　discuss　the　seismic　response　and　failure　mechanism　of　interaction　system　of　subway　station　in　saturated　soft　soil,　and　investigate　the　effects　of　the　parameter　variation　of　soft　soil　properties　typical　dynamic　response　indices　including　excess　pore　pressure　ratio　and　structural　internal　forces,　both　numerical　computation　and　corresponding　parametric　analyses　are　conducted　by　using　the　dynamic　method　of　two-phase　porous　media　and　the　method　of　multi-index　comprehensive　balance,　which　can　provide　reference　for　the　understanding　of　disaster　mechanism　and　seismic　design　of　subway　station　in　saturated　soft　soil　ground.　Research　conclusions:(1)　There　is　an　annular　peak　zone　of　dynamic　pore　pressure　near　the　floor　plate　and　the　subsoil　moves　from　two　flanks　which　leads　to　the　uplift　of　subway　station.　(2)　The　middle　floor　plate,　underpart　of　shear　wall　and　middle　column　are　weak　parts　during　seismic　action.　(3)　Cohesion　of　soft　soil　is　the　most　sensitive　soil　parameter　to　typical　dynamic　response　indices　and　reference　bulk　modulus　takes　the　second　place.(4)　The　research　results　can　be　employed　for　guiding　the　seismic　design　of　subway　station　surrounded　by　soft　soil.　©　2017,　Editorial　Department　of　Journal　of　Railway　Engineering　Society.　All　right　reserved.