In　a　bus　line　with　high　passenger　demand,　the　stop-skipping　operation　can　benefit　both　users　and　operators　as　well　as　improve　the　service　level　of　bus　line,　but　it　usually　cannot　be　effectively　adopted　by　operators　because　of　the　unordered　operation　of　buses　and　the　discomfort　of　waiting　passenger　at　stops.　Therefore,　the　stop-skipping　operation　requires　higher　reliability　for　stop　serving.　This　paper　proposes　a　reliable　stop-skipping　service　design　with　holding　strategy　by　taking　into　account　bus　capacity　constraints.　Under　a　stop-skipping　service,　the　holding　strategy　is　used　to　balance　the　interval　of　stop　serving　rather　than　the　headway　of　buses.　Meanwhile,　to　reflect　the　actual　boarding　process　of　waiting　passengers,　the　number　of　left-over　passengers　and　the　waiting　time　are　calculated　during　serving　time　and　holding　time,　respectively.　The　objective　function　is　to　minimize　the　total　costs　of　bus　operation　system.　Besides,　a　Genetic　Algorithm　combined　with　Monte　Carlo　Simulation　method　is　defined　and　implemented　to　solve　the　reliability　optimization　model.　Finally,　a　numerical　example　based　on　a　bus　route　in　Changchun　city　is　carried　out　to　test　the　reliability　optimization　model.　Results　showed　that　the　reliability　optimization　strategy　can　improve　the　stability　of　stop　service　and　then　save　cost　of　passengers＇　travel　time.