For　further　improving　the　catalytic　performance　of　VOx/MSU-1　in　the　reaction　of　oxidative　dehydrogenation　of　isobutane　to　isobutene　with　CO2,　in　this　paper,　a　series　of　modified　VOx/MSU-1　catalysts　were　prepared　using　MSU-1　as　the　supports　and　La,　Ce,　Cu　and　K　as　the　performance　modifier,　and　then　their　reaction　activity　were　evaluated　systematically.　Meanwhile,　La1.0V10.0/MSU-1　w(VOx)=10.0%,　w(La2O3)=1.0%　was　characterized　by　XRD,　H2-TPR　and　NH3-TPD　methods　and　the　reaction　conditions　were　investigated.　The　results　showed　that　La　addition　could　improve　not　only　the　dispersion　of　VOx　species,　active　components,　over　MSU-1　support　but　also　the　acid-base　properties　of　catalysts　surface,　which　was　favorable　to　the　oxidative　dehydrogenation　of　isobutane.　Under　the　optimal　reaciton　conditions　(temperature　was　853　K;　gas　hourly　space　velocity　was　4800　h-1;　pressures　was　atmospheric;　volume　ratio　of　CO2　and　isobutane　was　3:1),　isobutane　conversion　was　63.6%　and　isobutene　yield　was　52.3%　using　La1.0V10.0/MSU-1　as　the　catalyst.　At　last,　it　was　demonstrated　by　the　stability　experiments　of　8　h　that　La1.0V10.0/MSU-1　possessed　higher　catalytic　stability　than　V10.0/MSU-1　w(VOx)=10.0%,　isobutane　conversion　decreasing　to　16.5%　over　V10.0/MSU-1　in　contrast　to　28.8%　over　La1.0V10.0/MSU-1.　©　2017,　Editorial　Office　of　FINE　CHEMICALS.　All　right　reserved.