In　this　study,　a　porous　framework　MOF-74(Zn)　(Zn-2　(DFIBDC)(OMF)(H2O)(2),　H(4)dondc　=　1,　5-dioxido-2,　6-naphthalenedicarboxylic　acid)　with　open　metal　sites　was　successful　synthesized.　MOF-74(Zn)　as　a　template　was　grafted　on　the　open　metal　sites　with　ethylenediamine　(en)　named　MOF-74(Zn)-en　to　develop　a　highly　selective　and　sensitive　fluorescence　detector　for　rapid　determination　of　tetrabromobisphenol　A　(TBBPA).　The　obtained　MOF-74(Zn)-en　was　well　characterized　by　Fourier　Transform　Infrared　(FT-IR),　Scanning　Electron　Microscopy　(SEM)　and　showed　ideal　properties　of　photoluminescence.　The　fluorescence　enhancement　showed　a　good　linear　relationship　with　the　concentrations　of　TBBPA　in　the　range　of　50-400　mu　g/L,　and　its　limit　of　detection　could　reach　to　0.75　mu　g/L.　Furthermore,　the　possible　sensing　mechanism　of　the　fluorescence　enhancement　could　be　attributed　to　Forster　resonance　energy　transfer　(FRET).　The　results　will　provide　a　convenient　and　quick　method　for　detection　of　TBBPA.　To　the　best　of　my　knowledge,　this　is　the　first　case　to　detect　TBBPA　by　fluorescence　enhancement　with　MOF　derivatives.