The　broad　spectrum　detection　of　veterinary　drugs　is　very　important　for　rapid　and　large-scale　safe　screen　of　animal-derived　foods.　Metal-organic　frameworks　(MOFs),　as　a　kind　of　emerged　functional　porous　materials　are　quite　promising　in　the　chemical　sensing　and　molecular　detection.　In　this　work,　we　report　the　high-performance　broad　spectrum　detection　of　15　commonly-used　veterinary　drugs　through　the　fluorescence　quenching　in　a　newly-designed　chemically　stable　Al-based　MOF,　Al-3(mu(3)-O)(OH)(H2O)(2)(PPTTA)(3/2)　(BUT-22).　To　the　best　of　our　knowledge,　this　is　the　first　systematic　investigation　for　the　application　of　MOFs　in　the　detection/sensing　of　veterinary　drugs　through　fluorescence　quenching　method.　The　quenching　efficiencies　of　the　tested　veterinary　drugs　on　BUT-22　are　all　beyond　82%,　and　the　limits　of　detection　(LOD)　are　low　at　parts　per　billion　(ppb)　levels.　Interestingly,　BUT-22　also　enables　the　selective　detection　of　nicarbazin　(NIC)　through　the　clearly-observed　red　shift　of　its　maximum　fluorescence　emission　wavelength.　Moreover,　the　fluorescence　quenching　mechanism　was　explored　with　the　help　of　theoretical　calculations.　Our　work　indicates　that　MOFs　are　favorable　materials　for　the　detection　of　veterinary　drugs,　being　potentially　useful　in　monitoring　drug　residues　of　animal-derived　foods.