To　develop　a　new　type　of　three-dimensional　(3D)　isolator　proposed　by　authors　and　investigate　seismic　responses　and　3D　isolation　effect　of　3D　isolated　continuous　girder　bridges　under　different　seismic　intensities　and　characteristics,　a　1/25　scaled　three-span　continuous　girder　bridge　with　3D　isolator　bearing　(3DIB)　and　a　single-span　girder　bridge　with　the　common　natural　rubber　bearing　(NRB)　only　for　horizontal　isolation　were　designed　and　manufactured.　The　3DIB　and　NRB　were　designed　and　selected　for　the　bridge　model　test.　On　this　basis,　the　horizontal　and　vertical　seismic　simulation　shaking　table　tests　were　respectively　carried　out　on　the　three-span　and　single-span　isolated　continuous　girder　bridge　models.　The　results　show　that　the　developed　3D　isolation　bearing　takes　effect　safely　and　effectively　with　no　damage　under　almost　all　seismic　excitations　after　the　test.　There　is　no　damage　on　three-dimensional　isolation　bearing　after　the　test.　Under　the　horizontal　earthquake　action,　both　3DIB　and　NRB　reveal　favorable　horizontal　isolation　effect　with　50%-80%　for　horizontal　acceleration　of　main　girders.　The　horizontal　isolation　effect　of　3DIB　with　lead-core　laminated　rubber　component　is　obviously　better　than　that　of　NRB　under　near-fault　pulse-like　ground　motions.　Under　the　vertical　seismic　action,　the　peak　vertical　acceleration　of　the　single-span　girder　isolated　by　NRB　may　obviously　increase.　The　maximum　acceleration　may　be　double　that　of　the　original　one.　The　amplitude　may　be　enlarged　in　some　time　although　the　peak　value　is　not　amplified　in　some　excitations.　The　peak　vertical　acceleration　of　the　continuous　girder　with　3DIB　will　decrease　by　30%,　even　up　to　50%,　and　there　is　basically　no　local　amplification　in　some　time.　The　3D　isolated　bridge　shows　satisfactory　isolation　effect　under　horizontal　and　vertical　seismic　excitations,　which　provides　the　valuable　basis　for　3D　isolation　technology　applied　in　the　bridge　engineering.　©　2017,　Editorial　Department　of　China　Journal　of　Highway　and　Transport.　All　right　reserved.