Although　auxetic　(negative　Poisson＇s　ratio)　materials　and　structures　have　unique　mechanical　properties,　their　application　in　earthquake-resistant　structures　is　rarely　reported.　This　paper　proposed　a　novel　Auxetic　Perforated　Steel　Plate　Shear　Wall　(AP-SPSW)　for　seismic　mitigation　in　building　structures.　The　AP-SPSW　incorporates　the　unique　mechanical　properties　of　auxetic　materials　and　structures　to　reduce　out-of-plane　buckling　and　improve　seismic　performance　of　SPSWs.　Both　elliptical　and　peanut-shaped　perforation　configurations　were　proposed　for　the　AP-SPSW.　Through　small-scale　numerical　simulations　of　the　auxetic　unit　cells,　the　deformation　mode　of　the　auxetic　perforated　material　was　discussed　and　a　preliminary　design　was　presented　to　ensure　the　materials　with　negative　Poisson＇s　ratio.　In　addition,　ten　AP-SPSW　specimens　were　prepared　for　cyclic　loading　tests,　which　demonstrated　that　the　AP-SPSW　possesses　stable　hysteresis　behavior　and　excellent　energy　dissipation　capacity.　Key　parameters　affecting　the　hysteresis　performance　of　the　AP-SPSW　were　identified　as　porosity　of　the　perforated　panel　and　thickness　of　the　ligament　between　neighboring　perforations.　This　study　also　focused　on　the　global　shear　buckling　behavior　of　the　auxetic　perforated　panel　plates.　It　was　found　that　the　auxetic　deformation　mechanism　benefits　shear　buckling　resistance　in　the　SPSW　panel.　Finally,　an　analytical　model　was　proposed　for　the　shear　strength　of　the　auxetic　panel.　The　limitations　of　this　study　were　also　discussed,　along　with　the　work　required　for　further　exploration.　The　results　of　this　study　provide　valuable　insights　for　the　development　of　innovative　seismic-resistant　structures　that　incorporate　auxetic　materials　and　structures.