Regional　comprehensive　disaster　prevention　system　is　an　open,　extremely　complex　giant　system.　Continuous　development　and　evolution　of　the　complex　system　was　prompted　by　complex　nonlinear　interaction　between　the　groups.　Its　evolution　followed　the　generalized　entropy　principle.　From　the　macro-structure　of　regional　integrated　disaster　prevention　system　and　information　perspective,　regional　comprehensive　disaster　prevention　system　was　regarded　as　a　real　and　information　process.　By　introducing　the　maximum　entropy　and　maximum　flow　principle,　the　information　dynamics　model　for　evolution　of　the　regional　integrated　disaster　prevention　system　was　established　to　describe　and　control　its　evolution,　and　the　numerical　simulation　of　the　model　was　achieved　in　combination　with　self-organizing　feature　map　network.　The　model　reveals　the　laws　of　dynamics　on　the　formation　and　evolution　of　the　structure　pattern　of　regional　comprehensive　disaster　prevention　system.　The　integrated　earthquake　disaster　prevention　system　of　Nantong　city　during　2002-2008　was　studied　as　a　typical　example　for　numerical　simulation　and　network　structure　analysis.　The　results　show　that　the　system　structure　ξ　increases　from　0.06　to　4.19　year　by　year,　and　the　connection　weights　are　rationalized.　The　system　structure　is　stable　equilibrium.　Then　the　feasibility　and　rationality　of　the　model　is　verified.　It　provides　a　new　way　of　thinking　for　assessment,　prediction　and　regulation　of　the　evolution　of　the　regional　disaster　prevention　system.　©,　2015,　Central　South　University　of　Technology.　All　right　reserved.