This　paper　studies　the　effects　of　coronary　artery　stenosis　of　intermediate　severity　on　atherosclerotic　process　using　fluid-structure　interaction　method.　The　aim　of　the　study　was　to　analysis　the　impact　of　area　stenosis　(AS　=　50%,　65%,　75%)　and　lesion　length　(LL　=　10　mm,　15　mm,　20　mm)　on　hemodynamic　parameters.　Through　numerical　simulations,　it　is　found　that　a　big　margin　of　oscillating　wall　shear　stress　was　generated　in　the　branch　of　coronary　artery　stenosis　and　a　low　wall　shear　stress　was　generated　in　the　downstream　of　stenosis　when　area　stenosis　and　lesion　length　increase.　The　length　of　the　recirculation　zone　downstream　of　the　stenosis　will　present　with　S-shaped　growth　and　the　maximum　shear　rate　will　grow　as　parabolic　at　the　same　time.　In　addition,　stenosis　can　bring　about　a　significant　decline　in　pressure.　Hemodynamic　parameters　results　show　that,　intermediate　severity　area　stenosis　and　lesion　length　are　the　factors　may　cause　thrombosis,　clinical　should　attach　importance　to　it.　©　2015,　Editorial　Office　of　Chinese　Journal　of　Theoretical　and　Applied　Mechanics.　All　right　reserved.