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作者:

Liu, Lingyu (Liu, Lingyu.) | Lin, Lan (Lin, Lan.) | Sun, Shen (Sun, Shen.) | Wu, Shuicai (Wu, Shuicai.) (学者:吴水才)

收录:

Scopus SCIE

摘要:

Accelerated brain aging (ABA) intricately links with age-associated neurodegenerative and neuropsychiatric diseases, emphasizing the critical need for a nuanced exploration of heterogeneous ABA patterns. This investigation leveraged data from the UK Biobank (UKB) for a comprehensive analysis, utilizing structural magnetic resonance imaging (sMRI), diffusion magnetic resonance imaging (dMRI), and resting-state functional magnetic resonance imaging (rsfMRI) from 31,621 participants. Pre-processing employed tools from the FMRIB Software Library (FSL, version 5.0.10), FreeSurfer, DTIFIT, and MELODIC, seamlessly integrated into the UKB imaging processing pipeline. The Lasso algorithm was employed for brain-age prediction, utilizing derived phenotypes obtained from brain imaging data. Subpopulations of accelerated brain aging (ABA) and resilient brain aging (RBA) were delineated based on the error between actual age and predicted brain age. The ABA subgroup comprised 1949 subjects (experimental group), while the RBA subgroup comprised 3203 subjects (control group). Semi-supervised heterogeneity through discriminant analysis (HYDRA) refined and characterized the ABA subgroups based on distinctive neuroimaging features. HYDRA systematically stratified ABA subjects into three subtypes: SubGroup 2 exhibited extensive gray-matter atrophy, distinctive white-matter patterns, and unique connectivity features, displaying lower cognitive performance; SubGroup 3 demonstrated minimal atrophy, superior cognitive performance, and higher physical activity; and SubGroup 1 occupied an intermediate position. This investigation underscores pronounced structural and functional heterogeneity in ABA, revealing three subtypes and paving the way for personalized neuroprotective treatments for age-related neurological, neuropsychiatric, and neurodegenerative diseases.

关键词:

advanced brain aging structural MRI accelerated brain aging heterogeneity subtypes

作者机构:

  • [ 1 ] [Liu, Lingyu]Beijing Univ Technol, Coll Chem & Life Sci, Dept Biomed Engn, Beijing 100124, Peoples R China
  • [ 2 ] [Lin, Lan]Beijing Univ Technol, Coll Chem & Life Sci, Dept Biomed Engn, Beijing 100124, Peoples R China
  • [ 3 ] [Sun, Shen]Beijing Univ Technol, Coll Chem & Life Sci, Dept Biomed Engn, Beijing 100124, Peoples R China
  • [ 4 ] [Wu, Shuicai]Beijing Univ Technol, Coll Chem & Life Sci, Dept Biomed Engn, Beijing 100124, Peoples R China
  • [ 5 ] [Lin, Lan]Beijing Univ Technol, Intelligent Physiol Measurement & Clin Translat, Beijing Int Base Sci & Technol Cooperat, Beijing 100124, Peoples R China
  • [ 6 ] [Sun, Shen]Beijing Univ Technol, Intelligent Physiol Measurement & Clin Translat, Beijing Int Base Sci & Technol Cooperat, Beijing 100124, Peoples R China
  • [ 7 ] [Wu, Shuicai]Beijing Univ Technol, Intelligent Physiol Measurement & Clin Translat, Beijing Int Base Sci & Technol Cooperat, Beijing 100124, Peoples R China

通讯作者信息:

  • [Lin, Lan]Beijing Univ Technol, Coll Chem & Life Sci, Dept Biomed Engn, Beijing 100124, Peoples R China;;[Lin, Lan]Beijing Univ Technol, Intelligent Physiol Measurement & Clin Translat, Beijing Int Base Sci & Technol Cooperat, Beijing 100124, Peoples R China

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来源 :

BIOENGINEERING-BASEL

年份: 2024

期: 2

卷: 11

4 . 6 0 0

JCR@2022

被引次数:

WoS核心集被引频次:

SCOPUS被引频次: 2

ESI高被引论文在榜: 0 展开所有

万方被引频次:

中文被引频次:

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