Surface　wettability　has　a　significant　effect　on　the　heat　transfer　characteristics　of　the　flat　plate　heat　pipe　array　(FPHPA).　In　this　study,　an　aluminum　based　FPHPA　measuring　250　x　100　x　3　mm3,　comprising　of　9　independent　channels,　was　developed　to　investigate　the　impact　on　wettability　segmented　modification　through　experiment　and　simulation.　After　chemical　etching,　the　micro-nano　structure　of　the　surface　can　produce　a　hydrophilic　effect,　while　hydrophobic　effect　can　be　achieved　after　spraying　polydimethylsiloxane　mixture,　and　the　two　modification　methods　passed　the　heat　resistance　and　durability　tests.　The　FPHPA,　equipped　with　a　hydrophilic　evaporator,　a　hydrophobic　adiabatic,　and　a　condenser,　exhibited　enhanced　heat　transfer　characteristics,　lower　wall　temperature,　a　higher　heat　transfer　limit,　and　reduced　sensitivity　to　inclination　angle.　Simulation　results　revealed　that　the　hydrophilic　surface　promoted　bubbles　to　break　away　from　the　wall　surface　and　improved　the　critical　heat　flux　of　the　evaporator,　while　the　hydrophobic　surface　had　a　faster　droplet　return　rate　and　a　thinner　liquid　film　thickness,　which　improved　the　convective　heat　transfer　coefficient　of　the　condenser.　Compared　to　conventional　flat　heat　pipes,　hybrid　wetting　modified　FPHPA　shows　a　higher　overall　effective　thermal　conductivity　at　thermal　powers　above　90　W.　The　findings　from　this　study　contribute　to　a　better　understanding　of　the　heat　transfer　mechanism　following　surface　modification　and　offer　a　practical　method　for　modifying　FPHPA.