Mixed　matrix　membranes　exhibit　enhanced　selectivity　and　permeability,　but　stability　still　needs　to　be　improved.　In　this　study,　we　prepared　ZIF-8/PEBA　mixed　matrix　membranes　with　different　loadings　and　used　interface　induction　to　control　the　directional　distribution　of　nanoparticles.　The　controlled　directional　distribution　of　ZIF-8　in　PEBA　was　studied　by　optical　microscopy　and　scanning　electron　microscopy.　The　effects　of　different　ZIF-8　loading　amounts　on　the　formation　and　pervaporation　performance　of　mixed　matrix　membranes　were　thoroughly　studied.　The　prepared　membrane　was　applied　to　1　wt%　n-butanol　aqueous　solution,　achieving　a　high　flux　of　4.9　kg　m-　2　h-1　and　a　separation　factor　of　18.8.　The　directional　distribution　of　nanoparticles　in　PEBA　prevents　direct　contact　with　the　feed　liquid　and　effectively　protects　the　structural　stability　of　ZIF-8.　The　resulting　ZIF-8/　PEBA　membrane　showed　excellent　stability　after　more　than　100　h　of　operation.