Conversion　of　carbon　dioxide　(CO2)　to　valuable　chemicals　and　feedstocks　through　electrochemical　reduction　holds　promise　for　achieving　carbon　neutrality　and　mitigating　global　warming.　C2+　products　are　of　interest　due　to　their　higher　economic　value.　Since　the　CO(2　)to　C2+　conversion　process　involves　multiple　steps,　tandem　catalytic　strategies　are　commonly　employed　in　the　design　of　electrochemical　CO(2　)reduction　reaction　(CO2RR)　catalysts　and　systems/reactors.　Among　the　diverse　catalysts　that　are　capable　of　reducing　CO2　to　CO,　Cu　stands　out　for　more　efficiently　further　converting　CO　to　C2+　products.　In　this　review,　the　emerging　Cu-based　tandem　catalysts　and　their　impact　on　CO2RR　performance,　focusing　on　three　positional　relationships　are　summarized.　It　delves　into　the　integration　of　tandem　catalytic　strategies　into　membrane　electrolyzers,　utilizing　catalyst-coated　substrate　(CCS)　and　catalyst-coated　membrane　(CCM)　technologies.　Several　typical　examples　are　presented　to　illustrate　this　integration.　Finally,　the　challenges　and　prospects　of　applying　tandem　strategies　in　the　development　of　CO2RR　catalysts/systems,　as　well　as　their　device-level　implementation　are　indicated.