Body-centred　cubic　refractory　multi-principal　element　alloys　(MPEAs),　with　several　refractory　metal　elements　as　constituents　and　featuring　a　yield　strength　greater　than　one　gigapascal,　are　promising　materials　to　meet　the　demands　of　aggressive　structural　applications1-6.　Their　low-to-no　tensile　ductility　at　room　temperature,　however,　limits　their　processability　and　scaled-up　application7-10.　Here　we　present　a　HfNbTiVAl10　alloy　that　shows　remarkable　tensile　ductility　(roughly　20%)　and　ultrahigh　yield　strength　(roughly　1,390　megapascals).　Notably,　these　are　among　the　best　synergies　compared　with　other　related　alloys.　Such　superb　synergies　derive　from　the　addition　of　aluminium　to　the　HfNbTiV　alloy,　resulting　in　a　negative　mixing　enthalpy　solid　solution,　which　promotes　strength　and　favours　the　formation　of　hierarchical　chemical　fluctuations　(HCFs).　The　HCFs　span　many　length　scales,　ranging　from　submicrometre　to　atomic　scale,　and　create　a　high　density　of　diffusive　boundaries　that　act　as　effective　barriers　for　dislocation　motion.　Consequently,　versatile　dislocation　configurations　are　sequentially　stimulated,　enabling　the　alloy　to　accommodate　plastic　deformation　while　fostering　substantial　interactions　that　give　rise　to　two　unusual　strain-hardening　rate　upturns.　Thus,　plastic　instability　is　significantly　delayed,　which　expands　the　plastic　regime　as　ultralarge　tensile　ductility.　This　study　provides　valuable　insights　into　achieving　a　synergistic　combination　of　ultrahigh　strength　and　large　tensile　ductility　in　MPEAs.　A　HfNbTiVAl10　alloy　shows　tensile　ductility　and　ultrahigh　yield　strength　from　the　addition　of　aluminium　to　a　HfNbTiV　alloy,　resulting　in　a　negative　mixing　enthalpy　solid　solution,　which　promotes　strength　and　favours　formation　of　hierarchical　chemical　fluctuations.