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Author:

Liu, Jinduo (Liu, Jinduo.) | Zhai, Jihao (Zhai, Jihao.) | Ji, Junzhong (Ji, Junzhong.) (Scholars:冀俊忠)

Indexed by:

Scopus SCIE

Abstract:

Inferring causal protein signalling networks from human immune system cell data is a promising approach to unravel the underlying tissue signalling biology and dysfunction in diseased cells, which has attracted considerable attention within the bioinformatics field. Recently, Bayesian network (BN) techniques have gained significant popularity in inferring causal protein signalling networks from multiparameter single-cell data. However, current BN methods may exhibit high computational complexity and ignore interactions among protein signalling molecules from different single cells. A novel BN method is presented for learning causal protein signalling networks based on parallel discrete artificial bee colony (PDABC), named PDABC. Specifically, PDABC is a score-based BN method that utilises the parallel artificial bee colony to search for the global optimal causal protein signalling networks with the highest discrete K2 metric. The experimental results on several simulated datasets, as well as a previously published multi-parameter fluorescence-activated cell sorter dataset, indicate that PDABC surpasses the existing state-of-the-art methods in terms of performance and computational efficiency.

Keyword:

bioinformatics data mining swarm intelligence intelligent signal processing computational intelligence machine learning

Author Community:

  • [ 1 ] [Liu, Jinduo]Beijing Univ Technol, Beijing Artificial Intelligence Inst, Fac Informat Technol, Beijing Key Lab Multimedia & Intelligent Software, Beijing, Peoples R China
  • [ 2 ] [Zhai, Jihao]Beijing Univ Technol, Beijing Artificial Intelligence Inst, Fac Informat Technol, Beijing Key Lab Multimedia & Intelligent Software, Beijing, Peoples R China
  • [ 3 ] [Ji, Junzhong]Beijing Univ Technol, Beijing Artificial Intelligence Inst, Fac Informat Technol, Beijing Key Lab Multimedia & Intelligent Software, Beijing, Peoples R China

Reprint Author's Address:

  • [Ji, Junzhong]Beijing Univ Technol, Beijing Artificial Intelligence Inst, Fac Informat Technol, Beijing Key Lab Multimedia & Intelligent Software, Beijing, Peoples R China;;

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Source :

CAAI TRANSACTIONS ON INTELLIGENCE TECHNOLOGY

ISSN: 2468-6557

Year: 2024

5 . 1 0 0

JCR@2022

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 1

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