Alterations　in　cellular　metabolism　are　important　hallmarks　of　glioblastoma(GBM).　Metabolic　reprogramming　is　a　critical　feature　as　it　meets　the　higher　nutritional　demand　of　tumor　cells,　including　proliferation,　growth,　and　survival.　Many　genes,　proteins,　and　metabolites　associated　with　GBM　metabolism　reprogramming　have　been　found　to　be　aberrantly　expressed,　which　may　provide　potential　targets　for　cancer　treatment.　Therefore,　it　is　becoming　increasingly　important　to　explore　the　role　of　internal　and　external　factors　in　metabolic　regulation　in　order　to　identify　more　precise　therapeutic　targets　and　diagnostic　markers　for　GBM.　In　this　review,　we　define　the　metabolic　characteristics　of　GBM,　investigate　metabolic　specificities　such　as　targetable　vulnerabilities　and　therapeutic　resistance,　as　well　as　present　current　efforts　to　target　GBM　metabolism　to　improve　the　standard　of　care.