A　dynamic　model　for　isolated　high-rise　frame-shear　wall　buildings　was　presented　based　on　the　consideration　of　interaction　of　frame　and　shear　wall,　in　which　the　shear　wall　is　a　system　with　distributed　mass　and　the　frame　is　a　system　with　lumped　mass　and　spring.　According　to　established　dynamic　model,　the　effects　of　isolated　devices　and　the　frame　structure　on　the　shear　wall　structure　were　introduced　into　a　distributed　parameter　system　using　boundary　conditions,　and　frequency　equation　and　mode　orthogonal　conditions　were　deduced.　Then,　according　to　the　Hamilton　Principle,　the　equivalent　damping　ratio　in　every　mode　produced　by　the　damping　of　laminated　rubber　bearings　was　derived,　and　the　seismic　response　of　isolated　high-rise　frame-shear　wall　buildings　can　be　obtained　by　the　mode　superposition　method.　Finally,　a　ten-story　isolated　frame-shear　wall　building　was　chosen　to　analyze　dynamic　characteristics　and　seismic　response　to　validate　the　correctness　of　the　dynamic　model　and　method　of　solving　for　seismic　response.　Simulation　results　show　that　the　established　dynamic　model　can　reflect　the　dynamic　performance　of　isolated　structure　well　and　seismic　response　of　isolated　high-rise　frame-shear　wall　buildings　can　be　solved　conveniently　by　the　method　in　this　paper,　the　results　of　which　are　basically　consistent　with　those　from　finite　element　methods.　At　the　same　time,　the　method　deduced　can　obtain　the　interaction　process　of　frame　structures　and　shear-wall　structures　in　isolated　high-rise　frame-shear　wall　buildings.　©,　2015,　Tsinghua　University.　All　right　reserved.