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Author:

Huang, Qiumei (Huang, Qiumei.) (Scholars:黄秋梅) | Qiao, Zhonghua (Qiao, Zhonghua.) | Yang, Huiting (Yang, Huiting.)

Indexed by:

EI Scopus SCIE

Abstract:

Prostate cancer (PCa) is a significant global health concern that affects the male population. In this study, we present a numerical approach to simulate the growth of PCa tumors and their response to drug therapy. The approach is based on a previously developed model, which consists of a coupled system comprising one phase field equation and two reaction-diffusion equations. To solve this system, we employ the fast second -order exponential time differencing Runge-Kutta (ETDRK2) method with stabilizing terms. This method is a decoupled linear numerical algorithm that preserves three crucial physical properties of the model: a maximum bound principle (MBP) on the order parameter and non -negativity of the two concentration variables. Our simulations allow us to predict tumor growth patterns and outcomes of drug therapy over extended periods, offering valuable insights for both basic research and clinical treatments.

Keyword:

Maximum bound principle Prostate cancer tumor growth Exponential time differencing Runge-Kutta Phase field equation Non-negativity Drug therapy

Author Community:

  • [ 1 ] [Huang, Qiumei]Beijing Univ Technol, Fac Sci, Beijing 100875, Peoples R China
  • [ 2 ] [Yang, Huiting]Beijing Univ Technol, Fac Sci, Beijing 100875, Peoples R China
  • [ 3 ] [Qiao, Zhonghua]Hong Kong Polytech Univ, Dept Appl Math, Hung Hom, Hong Kong, Peoples R China

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Source :

COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING

ISSN: 0045-7825

Year: 2024

Volume: 426

7 . 2 0 0

JCR@2022

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count: 3

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 0

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