Developing　the　alternative　supported　noble　metal　catalysts　with　low　cost,　high　catalytic　efficiency,　and　good　resistance　toward　carbon　dioxide　and　water　vapor　is　critically　demanded　for　the　oxidative　removal　of　volatile　organic　compounds　(VOCs).　In　this　work,　we　prepared　the　mesoporous　chromia-supported　bimetallic　Co　and　Ni　single-atom　(Co1Ni1/meso-Cr2O3)　and　bimetallic　Co　and　Ni　nanoparticle　(CoNPNiNP/meso-Cr2O3)　catalysts　adopting　the　one-pot　polyvinyl　pyrrolidone　(PVP)-　and　polyvinyl　alcohol　(PVA)-protecting　approaches,　respectively.　The　results　indicate　that　the　Co1Ni1/meso-Cr2O3　catalyst　exhibited　the　best　catalytic　activity　for　n-hexane　(C6H14)　combustion　(T50%　and　T90%　were　239　and　263　°C　at　a　space　velocity　of　40,000　mL　g−1　h−1;　apparent　activation　energy　and　specific　reaction　rate　at　260　°C　were　54.7　kJ　mol−1　and　4.3　×　10−7　mol　gcat−1　s−1,　respectively),　which　was　associated　with　its　higher　(Cr5+　+　Cr6+)　amount,　large　n-hexane　adsorption　capacity,　and　good　lattice　oxygen　mobility　that　could　enhance　the　deep　oxidation　of　n-hexane,　in　which　Ni1　was　beneficial　for　the　enhancements　in　surface　lattice　oxygen　mobility　and　low-temperature　reducibility,　while　Co1　preferred　to　generate　higher　contents　of　the　high-valence　states　of　chromium　and　surface　oxygen　species　as　well　as　adsorption　and　activation　of　n-hexane.　n-Hexane　combustion　takes　place　via　the　Mars−van　Krevelen　(MvK)　mechanism,　and　its　reaction　pathways　are　as　follows:　n-hexane　→　olefins　or　3-hexyl　hydroperoxide　→　3-hexanone,　2-hexanone　or　2,5-dimethyltetrahydrofuran　→　2-methyloxirane　or　2-ethyl-oxetane　→　acrylic　acid　→　COx　→　CO2　and　H2O.　©　2022　Institute　of　Process　Engineering,　Chinese　Academy　of　Sciences