A　computational　hemodynamics　method　was　employed　to　investigate　how　the　morphotype　and　functional　state　of　aortic　valve　would　affect　the　characteristics　of　blood　flow　in　aortas　with　pathological　dilation,　especially　the　intensity　and　distribution　of　flow　turbulence.　Two　patient-specific　aortas　diagnosed　to　have　pathological　dilation　of　the　ascending　segment　while　differential　aortic　valve　conditions　(i.e.,　one　with　a　stenotic　and　regurgitant　RL　bicuspid　aortic　valve　(RL-BAV),　whereas　the　other　with　a　quasi-normal　tricuspid　aortic　valve　(TAV))　were　studied.　When　building　the　computational　models,　in　addition　to　in　vivo　data-based　reconstruction　of　geometrical　model　and　boundary　condition　setting,　the　large　eddy　simulation　method　was　adopted　to　quantify　potential　flow　turbulence　in　the　aortas.　Obtained　results　revealed　the　presence　of　complex　flow　patterns　(denoted　by　time-varying　changes　in　vortex　structure),　flow　turbulence　(indicated　by　high　turbulent　eddy　viscosity　(TEV)),　and　regional　high　wall　shear　stress　(WSS)　in　the　ascending　segment　of　both　aortas.　Such　hemodynamic　characteristics　were　significantly　augmented　in　the　aorta　with　RL-BAV.　For　instance,　the　space-averaged　TEV　in　late　systole　and　the　wall　area　exposed　to　high　time-averaged　WSS　(judged　by　WSS＞　two　times　of　the　mean　WSS　in　the　entire　aorta)　in　the　ascending　aortic　segment　were　increased　by　176%　and　465%,　respectively.　Relatively,　flow　patterns　in　the　descending　aortic　segment　were　less　influenced　by　the　aortic　valve　disease.　These　results　indicate　that　aortic　valve　disease　has　profound　impacts　on　flow　characteristics　in　the　ascending　aorta,　especially　the　distribution　and　degree　of　high　WSS　and　flow　turbulence.