For　tungsten　(W),　doping　with　second-phase　particles　is　a　commonly　employed　method　to　enhance　its　properties.　Experiments　have　observed　that　oxide　dispersion-strengthened　tungsten　alloys　(ODS-W)　exhibit　superior　and　more　stable　ultimate　tensile　strength　(UTS)　at　elevated　temperatures.　To　elucidate　this　phenomenon,　in　situ　tensile　deformation　experiments　were　conducted　on　ODS-W　using　transmission　electron　microscopy　at　temperatures　up　to　1273　K.　Under　the　influence　of　temperature　and　tensile　stress,　a　phase　transition　from　BCC　to　FCC　occurred　near　the　oxide　interfaces　in　W.　This　BCC-FCC　phase　transformation　was　corroborated　by　combining　molecular　dynamics　simulations　(MD)　with　density　functional　theory　(DFT),　confirming　that　the　transformed　FCC　W　matrix　possesses　an　exceptional　adhesion　work,　significantly　enhancing　the　bonding　strength　at　the　Woxide　interfaces.　Based　on　these　observations,　this　work　provides　a　plausible　explanation　for　the　high　UTS　retention　of　ODS-W　at　high　temperatures.　These　findings　offer　valuable　insights　into　the　development　of　oxidestrengthened　alloys　for　high-temperature　applications　and　present　a　novel　perspective　on　the　mechanisms　of　second-phase　reinforcement.