Mesoporous　carbon-silica　nanocomposites　have　been　successfully　synthesized　by　one-pot　co-assembly　method,　using　resorcinol　and　formaldehyde　as　carbon　precursor,　tetraethoxysilane　as　silica　precursor　and　triblock　copolymer　F127　as　template.　Mesoporous　carbon　with　higher　BET　surface　area　and　pore　volume　could　be　obtained　by　removing　the　silica　with　NaOH.　The　characterization　results　of　TEM　and　SAXRD　revealed　that　mesostrucetre　of　the　mesoporous　materials　changed　from　ordered　channel　to　disordered　worm-like　structures　before　and　after　the　additive　of　TEOS.　The　BET　surface　area　of　the　obtained　materials　increased　from　389　m2/g　to　602　m2/g,　and　pore　volumes　increased　from　0.45　cm3/g　to　0.58　cm3/g.　The　pore　size　of　the　mesoporous　composites　increased　from　7.48　nm　to　7.73　nm　slightly.　The　immobilization　amount　of　lysozyme　adsorbed　on　mesoporous　composties　increased　with　the　increase　of　the　BET　surface　area　and　pore　volume　of　mesoporus　materials.　The　immobilization　results　show　that　the　adsorption　process　of　the　pure　mesoporous　carbon　follow　the　Langmuir　isotherm　and　the　materials　with　higher　surface　area　and　pore　volume　follow　the　Freundlich　isotherm.