The　objective　of　this　study　was　to　explore　the　effects　of　myocardial　bridge　compression　on　blood　flow,　normal　stress,　circumferential　stress　and　shear　stress　in　mural　coronary　artery.　An　original　mural　coronary　artery　simulative　device　has　been　greatly　improved　and　its　measured　hemodynamic　parameters　have　been　expanded　from　a　single　stress　(normal　stress)　to　multiple　stresses　to　more　fully　and　accurately　simulate　the　true　hemodynamic　environment　under　normal　stress,　circumferential　stress　and　shear　stress.　This　device　was　used　to　more　fully　explore　the　relationship　between　hemodynamics　and　mural　coronary　atherosclerosis　under　the　combined　effects　of　multiple　stresses.　Results　obtained　from　the　mural　coronary　artery　simulator　showed　stress　abnormality　to　be　mainly　located　in　the　proximal　mural　coronary　artery　where　myocardial　bridge　compression　was　intensified　and　average　and　fluctuation　values　(maximum　minus　minimum)　of　proximal　stress　were　significantly　increased　by　27.8%　and　139%,　respectively.　It　is　concluded　that　myocardial　bridge　compression　causes　abnormalities　in　the　proximal　hemodynamics　of　the　mural　coronary　artery.　This　is　of　great　significance　for　understanding　the　hemodynamic　mechanism　of　coronary　atherosclerosis　and　has　potential　clinical　value　for　the　pathological　effect　and　treatment　of　myocardial　bridge.