To　improve　the　service　quality　of　service　robots　for　the　disabled,　immune　system　is　applied　on　robot　for　its　advantages　such　as　diversity,　dynamic,　parallel　management,　self-organization,　and　self-adaptation.　According　to　the　immune　system　theory,　local　environment　condition　sensed　by　robot　is　considered　an　antigen　while　robot　is　regarded　as　B-cell　and　possible　node　as　antibody,　respectively.　Antibody-antigen　affinity　is　employed　to　choose　the　optimal　possible　node　to　ensure　the　service　robot　can　pass　through　the　optimal　path.　The　paper　details　the　immune　system　applications　on　service　robot　and　gives　experimental　results.　©　2014　Songmin　Jia　et　al.