Preparation of pH-responsive bimodal mesoporous silicas and their performances in controlled ibuprofen delivery - 文章详情页

作者：

Guo, Yueyue (Guo, Yueyue.) | Bai, Shiyang (Bai, Shiyang.) | Sun, Jihong (Sun, Jihong.) (学者：孙继红)

收录：

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摘要：

The　pH-responsive　bimodal　mesoporous　SiO2　nanocomposite　(D-P/BMMs)　was　prepared　via　two-steps　method,　which　was　achieved　by　the　combination　of　pH-responsive　Dex-PAA　polymer　with　the　bimodal　mesoporous　silica　(BMMs).　The　structural　characteristics　and　textural　properties　of　the　resultant　D-P/BMMs　were　characterized　by　means　of　XRD,　SEM,　FT-IR,　TG　and　N2　adsorption-desorption　techniques,　which　demonstrated　that　the　mesoporous　ordered　degree　of　BMMs　was　decreased　because　of　coating　of　Dex-PAA　polymer.　Meanwhile,　the　pH-responsive　drug-controlled　delivery　was　systematically　investigated　by　using　ibuprofen　as　a　model　drug　under　phosphate　buffer　solutions　(PBS)　with　different　pH　values,　and　the　results　showed　that　the　releasing　yield　of　ibuprofen　was　up　to　46%　at　pH=7.4　more　than　that　at　pH=2.0　(around　26%),　suggesting　that　the　D-P/BMMs　nanocomposite　has　an　excellent　performance　of　pH-responsive　drug　delivery.

关键词：

Targeted drug delivery SiO2 nanoparticles Controlled drug delivery Silica Nanocomposites Polymers Mesoporous materials

作者机构：

[ 1 ] [Guo, Yueyue]College of Environmental and Energy Engineering, Beijing University of Technology, Beijing 100124, China
[ 2 ] [Bai, Shiyang]College of Environmental and Energy Engineering, Beijing University of Technology, Beijing 100124, China
[ 3 ] [Sun, Jihong]College of Environmental and Energy Engineering, Beijing University of Technology, Beijing 100124, China

通讯作者信息：

电子邮件地址：

jhsun@bjut.edu.cn

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