Due　to　the　influence　of　masonry　infill　walls,　the　effects　of　the　short　column　will　be　produced　in　the　reinforced　concrete　(RC)　frame　column,　and　the　RC　column　will　be　subject　to　serious　earthquake　damage.　In　the　field　of　masonry　infill　wall　RC　frame　structure　collapse　prevention　in　strong　earthquakes,　it　is　important　to　accurately　simulate　the　seismic　damage　behaviors　of　the　RC　frame　column　while　considering　the　influence　of　an　infill　wall　with　openings.　Firstly,　a　segmentation　equivalent　nonlinear　spring　simplified　model　is　proposed　to　consider　the　influence　of　the　infill　wall　with　openings,　and　the　value　of　the　restoring　spring　force　in　the　simplified　model　is　given.　Then,　based　on　the　simplified　model,　the　nonlinear　seismic　damage　behavior　of　an　RC　frame　column　in　an　actual　bottom　frame　structure　is　simulated,　and　the　numerical　simulation　results　are　compared　with　the　actual　earthquake　damage　to　verify　the　effectiveness　of　the　simplified　model.　Finally,　the　seismic　damage　evolution　mechanism　of　the　frame　column　in　the　bottom　frame　structure　is　analyzed,　and　the　influence　laws　of　the　infill　wall　with　openings　on　the　RC　frame　column　are　discussed.　The　research　shows　that　the　simplified　analysis　model　can　effectively　simulate　the　influence　of　infill　walls　with　openings　on　the　seismic　damage　of　the　RC　frame　column.　The　opening　infill　wall　leads　to　the　short　column　effect,　and　the　frame　column　can　easily　present　brittle　shear　failure.　Therefore,　the　seismic　design　of　the　frame　column　near　window-height　should　be　highly　considered.