In　recent　years,　among　the　causes　of　death　that　are　relatively　easy　to　induce,　the　death　rate　of　cardiovascular　disease　consistently　ranks　the　first　place　and　continues　to　rise　year　by　year.　The　calcium　signal　involved　in　calcium　ions　is　the　main　cause　of　cardiovascular　disease　at　the　microscopic　level.　Calcium　wave　is　one　of　the　representative　calcium　signals,　so　it　is　important　to　understand　its　mechanism.　The　diffusion　and　mechanism　of　calcium　waves　in　the　sarcoplasmic　reticulum　of　cardiomyocytes　were　studied　in　this　paper.　Based　on　the　spatial　diffusion　mechanism　of　calcium　waves　in　the　sarcoplasmic　reticulum,　a　numerical　calculation　model　of　calcium　waves　in　the　sarcoplasmic　reticulum　was　established　by　considering　the　physical　spatial　structure　of　calcium　waves,　the　dissociation　reaction　between　calcium　ions　and　other　substances,　and　the　transport　of　calcium　ions　by　calcium　pumps.　The　computer　program　was　used　to　simulate　the　calcium　waves　in　the　sarcoplasmic　reticulum.　The　model　in　this　paper　simulated　the　triggering　and　propagating　process　of　the　calcium　waves　in　the　local　myocardium.　©　2024　SPIE.