Background:　Meniere＇s　disease　(MD)　is　an　ear-related　vestibular　disorder　accompanied　by　vertigo,　hearing　loss,　and　tinnitus.　The　anatomical　structure　and　spatial　position　of　the　semicircular　canals　are　important　for　understanding　vestibular　function　and　disease;　however,　research　on　MD　and　the　effect　of　anatomical　changes　in　the　semicircular　canals　is　limited.　This　study　explored　the　relationship　between　the　spatial　location　of　the　semicircular　canals　and　MD　using　ultra-high-resolution　computed　tomography　(U-HRCT)　and　intelligent　segmentation.　Methods:　Isotropic　U-HRCT　images　obtained　from　patients　with　MD　and　healthy　controls　(HCs)　were　retrospectively　analyzed.　We　extracted　the　semicircular　canal　structures　and　extracted　their　skeleton.　The　plane　of　the　skeleton　of　each　semicircular　canal　was　fitted　separately.　The　mutual　angles　between　the　semicircular　canals,　and　the　angles　between　each　semicircular　canal　and　each　plane　of　the　coordinate　system　were　measured.　Results:　Among　45　MD-affected　ears　(MDAEs),　33　MD-healthy　ears　(MDHEs),　and　45　HC　ears,　the　angle　between　the　superior　and　lateral　semicircular　canals　(LSCs)　and　the　angle　between　the　superior　and　posterior　semicircular　canals　(PSCs)　were　larger　in　the　MDAE　and　MDHE　groups　than　the　HC　group　(P＜0.01),　while　the　angle　between　the　posterior　and　LSCs　was　smaller　in　the　MDAE　group　than　the　HC　group　(P＜0.001).　The　angles　between　the　superior　and　PSCs　and　coronal　plane　(CP)　of　the　coordinate　system　were　significantly　smaller　in　the　MDAE　and　MDHE　groups　than　the　HC　group　(P＜0.01);　however,　the　angles　between　the　LSC　and　axial　plane　and　CP　were　significantly　larger　in　the　MDAE　and　MDHE　groups　than　the　HC　group　(P＜0.001).　Conclusions:　Spatial　position　changes　in　the　semicircular　canals　may　be　the　anatomical　basis　of　MD.