Polystyrene nanoplastics enhance thrombosis through adsorption of plasma proteins - 文章详情页

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EI Scopus

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Plastic　products　offer　remarkable　convenience　for　modern　life.　However,　growing　concerns　are　emerging　regarding　the　potential　health　hazards　posed　by　nanoplastics,　which　formed　as　plastics　break　down.　Currently,　the　biological　effects　and　mechanisms　induced　by　nanoplastics　are　largely　underexplored.　In　this　study,　we　report　that　polystyrene　nanoplastics　can　enter　the　bloodstream　and　enhance　thrombus　formation.　Our　findings　show　that　polystyrene　nanoplastics　adsorb　plasma　proteins,　particularly　coagulation　factor　XII　and　plasminogen　activator　inhibitor-1,　play　a　key　role　in　this　process,　as　demonstrated　by　proteomics,　bioinformatic　analyses,　and　molecular　dynamics　simulations.　The　adsorption　of　these　proteins　by　nanoplastics　is　an　essential　factor　in　thrombosis　enhancement.　This　newly　uncovered　pathway　of　protein　adsorption　leading　to　enhanced　thrombosis　provides　new　insights　into　the　biological　effects　of　nanoplastics,　which　may　inform　future　safety　and　environmental　risk　assessment　of　plastics.　©　2024　Elsevier　B.V.

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Nanoclay

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[ 1 ] [Sheng, Chao]Beijing International Science and Technology Cooperation Base of Antivirus Drug, College of Chemistry and Life Science, Beijing University of Technology, Beijing; 100124, China
[ 2 ] [Wang, Guozhen]Beijing International Science and Technology Cooperation Base of Antivirus Drug, College of Chemistry and Life Science, Beijing University of Technology, Beijing; 100124, China
[ 3 ] [Wang, Guozhen]Clinical Laboratory, China-Japan Friendship Hospital, Beijing; 100029, China
[ 4 ] [Liu, Zijia]Beijing International Science and Technology Cooperation Base of Antivirus Drug, College of Chemistry and Life Science, Beijing University of Technology, Beijing; 100124, China
[ 5 ] [Zheng, Yuchen]Beijing International Science and Technology Cooperation Base of Antivirus Drug, College of Chemistry and Life Science, Beijing University of Technology, Beijing; 100124, China
[ 6 ] [Zhao, Zijie]Beijing International Science and Technology Cooperation Base of Antivirus Drug, College of Chemistry and Life Science, Beijing University of Technology, Beijing; 100124, China
[ 7 ] [Tang, Duo]Beijing International Science and Technology Cooperation Base of Antivirus Drug, College of Chemistry and Life Science, Beijing University of Technology, Beijing; 100124, China
[ 8 ] [Li, Wenzhuo]Beijing International Science and Technology Cooperation Base of Antivirus Drug, College of Chemistry and Life Science, Beijing University of Technology, Beijing; 100124, China
[ 9 ] [Li, Ao]Beijing International Science and Technology Cooperation Base of Antivirus Drug, College of Chemistry and Life Science, Beijing University of Technology, Beijing; 100124, China
[ 10 ] [Zong, Qi]Beijing International Science and Technology Cooperation Base of Antivirus Drug, College of Chemistry and Life Science, Beijing University of Technology, Beijing; 100124, China
[ 11 ] [Zhou, Renhang]School of Biomedicine, Beijing City University, Beijing; 100094, China
[ 12 ] [Hou, Xiaonan]Beijing International Science and Technology Cooperation Base of Antivirus Drug, College of Chemistry and Life Science, Beijing University of Technology, Beijing; 100124, China
[ 13 ] [Yao, Mengfei]Beijing International Science and Technology Cooperation Base of Antivirus Drug, College of Chemistry and Life Science, Beijing University of Technology, Beijing; 100124, China
[ 14 ] [Zhou, Zhixiang]Beijing International Science and Technology Cooperation Base of Antivirus Drug, College of Chemistry and Life Science, Beijing University of Technology, Beijing; 100124, China

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