Pt-based　alloy　nanocrystals　have　shown　great　success　in　oxygen　reduction　electrocatalysis　owing　to　their　unique　surface　and　electronic　structures.　However,　they　suffer　from　severe　stability　issues　due　to　the　dissolution　of　non-noble　metal　elements,　leading　to　the　＂trade-off＂　between　activity　and　stability.　In　this　work,　targeting　the　stability　issue　of　a　PtxCuy-based　alloy,　Pt2CuW0.25　ternary　alloy　nanoparticles　are　synthesized　by　thermal　reduction　strategy　based　on　wet-chemical　method　using　W(CO)(6)　as　a　reductant.　Apart　from　the　competitive　activity,　the　obtained　Pt2CuW0.25/C　shows　remarkable　stability,　whereby　the　area　specific　activity　and　mass　activity　maintain　89.5%　and　95.9%　of　the　initial　values,　respectively,　after　30　&　x202f;000　cycles　of　accelerated　polarization　between　0.6　and　1.1　V　(vs　reversible　hydrogen　electrode).　By　using　vacancy　formation　energy　of　surface　Pt　as　the　descriptor,　it　is　found　that　the　enhanced　stability　of　Pt2CuW0.25/C　originates　mainly　from　the　stronger　bonding　between　W　and　Pt/Cu　atoms,　acting　as　an　＂adhesive＂　to　stabilize　the　atoms　from　dissolution,　which　is　further　verified　by　chemical　stability　experiments.　This　work　demonstrates　a　rational　design　strategy　for　ternary　alloy　nano-electrocatalyst　that　has　high　thermodynamic　stability　while　maintaining　high　activity　by　employing　high-melting-point　metal.