Sixteen　reinforced　concrete　(RC)　circular　columns　strengthening　with　an　innovative　technique　using　prestressed　high　strength　steel　wire　mesh　(PSWM)　with　new　tensioning　and　anchor　system　and　two　contrast　columns　were　put　forward　to　research　the　seismic　strengthening　effects　of　main　experimental　parameters　being　axial　compressive　ratio,　steel　wire　spacing,　prestressing　level　of　steel　wire　under　cyclic　loading　and　constant　axial　load.　Test　results　show　that　the　yield　load,　ultimate　load,　ductility　coefficient　and　cumulative　dissipated　energy　of　the　high　and　low　axial　compressive　ratio　columns　are　36%,　44%,　76%,　62%　and　36%,　27%,　44%,　127%　greater　than　those　of　the　contrast　columns　respectively.　With　steel　wire　spacing　decreased,　seismic　strengthening　effect　is　greatly　improved.　The　stiffness　is　increased　and　the　stiffness　degradation　mitigated.　The　seismic　strengthening　effect　of　the　reinforced　columns　with　steel　wire　spacing　of　30　mm　did　not　change　significantly　with　increasing　of　prestressing　force　level.　The　presented　technology　is　an　active,　nondestructive,　and　efficient　strengthening　technique.