The　fire-induced　collapse　of　building　structures　is　the　mechanical　behavior　of　entire　structural　systems.　Due　to　the　difficulty　in　the　fire　test　for　overall　structural　systems,　numerical　simulation　is　an　important　method　to　study　the　global　behaviors　of　structures　under　fire.　The　fiber　beam　model,　multi-layer　shell　model　and　elemental　deactivation　technology　that　allows　for　the　effect　of　high　temperature　are　used　to　simulate　a　real　fire-induced　collapse　accident　of　a　frame-supported　masonry　building.　The　primary　reason　of　the　collapse　is　pointed　out.　Design　recommendations　to　improve　of　the　progressive　collapse　resistance　of　building　structures　are　also　proposed　based　on　the　numerical　results.