Diosgenin　is　an　important　precursor　for　production　of　steroidal　drugs　while　Dioscorea　zingiberensis　C.　H.　Wright,　is　the　most　popular　raw　material　for　diosgenin　production.　However,　wastewater　from　diosgenin　production　using　D.　zingiberensis　C.　H.　Wright　is　an　acidic　organic　wastewater　with　high　CODCrconcentration　and　deep　color.　Cleaner　production　is　an　effective　method　to　prevent　and　treat　the　wastewater.　Six　diosgenin　production　processes　from　D.　zingiberensis　C.　H.　Wright　were　evaluated　using　analytic　hierarchy　process　(AHP)-gray　relational　analysis.　Weights　of　12　indicators　(i.　e.　,　acid　consumption　coefficient,　water　consumption　coefficient,　energy　consumption　coefficient,　wastewater　production　index　per　ton　product,　waste　gas　production　index　per　ton　product,　solid　waste　production　index　per　ton　product,　pollutant　treatment　effect,　environmental　protection　cost,　environment　efficiency,　cost　investment,　operation　cost,　gains　of　conprehensive　resource　utilization)　were　determined　according　to　AHP.　Weights　of　water　consumption　coefficient,　wastewater　production　indicators,　and　the　acid　consumption　coefficient　were　0.216,　0.189,　and　0.167,　respectively,　as　the　top　three　indicatiors,　which　had　a　great　impact　on　evaluation　results.　By　steps　of　expert　scoring　and　structure　of　decision　matrix,　associate　degrees　between　process　indicators　column　and　data　columns　of　optimal　index　set　were　calculated.　Comprehensive　ranking　of　the　six　production　processes　was　obtained.　Cell　wall　breakdown　with　microwave-methanol　extraction,　whose　associate　degree　was　0.879,　was　optimal　process.　Direct　separation　method,　direct　separation-frame　filter　press,　saccharification-membrane　separation　recovery,　whose　associate　degree　was　0.874,　0.803,　0.701,　respectively,　successively　ranked　after　cell　wall　breakdown　with　microwave-methanol　extraction.　Direct　acid　hydrolysis　and　natural　fermentation-acid　hydrolysis,　whose　associate　degree　was　0.530,　0.410,　respectively,　ranked　the　last　two　and　could　be　considered　to　eliminate.　The　explorative　evaluation　and　the　results　were　expected　to　provide　a　reference　for　the　sound　development　of　industry　of　diosgenin　production　from　D.　zingiberensis　C.　H.　Wright　and　water　pollution　prevention,　etc.