(Ti,　Nb)C　particles　reinforced　Ni45　coatings　were　made　by　a　fiber　laser　system.　The　atomic　structure,　interfacial　stability,　interfacial　fracture　toughness,　electronic　structure　and　bonding　nature　of　gamma-Ni/(Ti,　Nb)C　were　systematically　analyzed　using　first　principles　calculations.　TEM　results　showed　that　the　interface　orientation　relationship　of　gamma-Ni/(Ti,　Nb)C　was　[0　(1)　over　bar0](202)//[00　(1)　over　bar](220).　For　the　gamma-Ni/(Ti,　Nb)C　interfaces,　the　stacking　sites　have　much　influence　than　the　substitution　position　of　Ti,　the　center-site　stacking　interfaces　shower　higher　adhesion　work　and　lower　interface　energy,　indicating　the　interfacial　alloying　or　new　phases　were　prone　to　formed.　According　to　the　interfacial　fracture　toughness　results,　the　mechanical　failure　of　gamma-Ni/(Ti,　Nb)C　may　initiate　at　the　interface　or　close　to　gamma-Ni　rather　than　(Ti,　Nb)C.　The　bonding　behavior　of　gamma-Ni/(Ti,　Nb)C　was　a　blend　of　covalent　bond　and　partial　ionic　bond.　The　chemical　bonding　properties　of　interfacial　atoms　were　also　discussed　in　view　of　electronic　structure　and　partial　density　of　states　(PDOS)　results.