The　influence　of　soil-structure　interaction　under　earthquake　excitation　should　be　considered　for　the　bridge-foundation　system,　especially　for　the　foundation　of　soft　soil.　A　1:10　scaled　model　of　a　four-span　continuous　girder　bridge　was　tested　on　shaking　tables　to　investigate　the　influence　of　soil-structure　interaction　on　seismic　response　of　the　bridge　model.　The　experimental　results　indicate　that　SSI　effect　increases　the　dynamic　response　of　the　bridge　model.　The　peak　of　the　response　monotonously　increases　as　the　shear　wave　velocity　decreases,　which　shows　the　shear　wave　velocity　is　an　important　factor　influencing　the　SSI　effect.　The　sensitivity　of　acceleration,　displacement　and　strain　to　SSI　effect　is　significantly　different.　The　acceleration　is　more　sensitive　to　SSI　effect　in　the　longitudinal　direction.　Furthermore,　SSI　effect　may　cause　dramatic　changes　in　the　relative　displacement　of　bearings.　The　test　results　verify　the　effectiveness　of　the　real-time　dynamic　hybrid　testing　technique.